Ontology highlight
ABSTRACT:
SUBMITTER: Ying Y
PROVIDER: S-EPMC5553710 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ying Yi Y Wang Xiao-Jun XJ Vuong Celine K CK Lin Chia-Ho CH Damianov Andrey A Black Douglas L DL
Cell 20170701 2
Proteins of the Rbfox family act with a complex of proteins called the Large Assembly of Splicing Regulators (LASR). We find that Rbfox interacts with LASR via its C-terminal domain (CTD), and this domain is essential for its splicing activity. In addition to LASR recruitment, a low-complexity (LC) sequence within the CTD contains repeated tyrosines that mediate higher-order assembly of Rbfox/LASR and are required for splicing activation by Rbfox. This sequence spontaneously aggregates in soluti ...[more]