Ontology highlight
ABSTRACT:
SUBMITTER: Begg BE
PROVIDER: S-EPMC7554199 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Begg Bridget E BE Jens Marvin M Wang Peter Y PY Minor Christine M CM Burge Christopher B CB
Nature structural & molecular biology 20200817 10
The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart and muscle. Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high affinity and specificity, but just half of Rbfox binding sites contain a GCAUG motif in vivo. We incubated recombinant RBFOX2 with over 60,000 mouse and human transcriptomic sequences to reveal substantial binding to several moderate-affinit ...[more]