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Rhodoterpenoids A?C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC?MS?SPE?NMR.


ABSTRACT: Rhodoterpenoids A?C (1?3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography-mass spectrometry-solid-phase extraction-nuclear magnetic resonance (HPLC?MS?SPE?NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1?4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87??M, respectively.

SUBMITTER: Liu F 

PROVIDER: S-EPMC5554136 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR.

Liu Fei F   Wang Ya-Nan YN   Li Yong Y   Ma Shuang-Gang SG   Qu Jing J   Liu Yun-Bao YB   Niu Chang-Shan CS   Tang Zhong-Hai ZH   Zhang Tian-Tai TT   Li Yu-Huan YH   Li Li L   Yu Shi-Shan SS  

Scientific reports 20170811 1


Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography-mass spectrometry-solid-phase extraction-nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacycli  ...[more]

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