Ontology highlight
ABSTRACT:
SUBMITTER: Trinh BTD
PROVIDER: S-EPMC6152321 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Trinh Binh Thi Dieu BTD Jäger Anna K AK Staerk Dan D
Molecules (Basel, Switzerland) 20170720 7
Protein tyrosine phosphatase 1B (PTP1B) plays a key role as a negative regulator in insulin signal transduction by deactivating the insulin receptor. Thus, PTP1B inhibition has emerged as a potential therapeutic strategy for curing insulin resistance. In this study, 40 extracts from 18 different plant species were investigated for PTP1B inhibitory activity in vitro. The most promising one, the EtOAc extract of <i>Ficus racemosa</i>, was investigated by high-resolution PTP1B inhibition profiling ...[more]