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CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study.

ABSTRACT: C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. Five single-nucleotide polymorphisms were analyzed: rs3093059, rs2794521, rs1417938, rs1800947, and rs1205. The generalized estimating equation approach was used to deal with correlated data within families. CRP level was positively correlated with diabetes prevalence and levels of fasting and 2-hour glucose (each P?

SUBMITTER: Sheu WH 

PROVIDER: S-EPMC5554245 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study.

Sheu Wayne Huey-Herng WH   Wang Wen-Chang WC   Wu Kwan-Dun KD   He Chih-Tsueng CT   Hwu Chii-Min CM   Quertermous Thomas T   Hsieh Wan-Shan WS   Lee Wen-Jane WJ   Ting Chih-Tai CT   Chen Yii-Der I YI   Hsiung Chao A CA  

Scientific reports 20170811 1

C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. F  ...[more]

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