Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC5554412 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Zhang Liqin L Yang Zunyi Z Le Trinh Thu T Teng I-Ting IT Wang Sai S Bradley Kevin M KM Hoshika Shuichi S Wu Qunfeng Q Cansiz Sena S Rowold Diane J DJ McLendon Christopher C Kim Myong-Sang MS Wu Yuan Y Cui Cheng C Liu Yuan Y Hou Weijia W Stewart Kimberly K Wan Shuo S Liu Chen C Benner Steven A SA Tan Weihong W
Angewandte Chemie (International ed. in English) 20160907 40
Laboratory in vitro evolution (LIVE) might deliver DNA aptamers that bind proteins expressed on the surface of cells. In this work, we used cell engineering to place glypican 3 (GPC3), a possible marker for liver cancer theranostics, on the surface of a liver cell line. Libraries were then built from a six-letter genetic alphabet containing the standard nucleobases and two added nucleobases (2-amino-8H-imidazo[1,2-a][1,3,5]triazin-4-one and 6-amino-5-nitropyridin-2-one), Watson-Crick complements ...[more]