Dataset Information

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

ABSTRACT:

Background

The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.

Methods

We conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of PID), and comorbidity. Cox proportional hazard regression was used to evaluate the risk of subsequent PD.

Results

At the final follow-up, a total of 176 (3.26%) and 275 (2.55%) individuals developed PD in the case and control groups, respectively. Patients with PID have a higher risk of developing PD (adjusted hazard ratio = 1.431, 95% CI [1.141-1.794], p = 0.002).

Discussion

Our results show that PID is associated with an increased risk of developing PD. Whilst these findings suggest that reducing PID may modify the risk of developing PD, further study will be needed.

SUBMITTER: Chen CK

PROVIDER: S-EPMC5554596 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Chen Chang-Kai CK Wu Yung-Tsan YT Chang Yu-Chao YC

PeerJ 20170810

<h4>Background</h4>The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.<h4>Methods</h4>We conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of P ...[more]

PMID: 28828251

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Project description:BackgroundSimilarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatric signs, the common use of medication, and bacterial translocation. One of several hypotheses for explaining the mechanisms underlying CFS suggests a similarity to the impaired intestinal mucosa of IBD. "This study investigated the risk of incident CFS among patients with IBD".MethodsWe conducted a population-based retrospective cohort study by using Taiwan's National Health Insurance Research Database to evaluate the subsequent risk of CFS in patients with IBD, according to demographic characteristics and comorbidities. The exposure cohort comprised 2163 patients with new diagnoses of IBD. Each patient was randomly selected and frequency matching according to gender and age with four participants from the general population who had no history of CFS at the index date (control cohort). Cox proportional hazards regression analysis was conducted to estimate the relationship between IBD and the subsequent risk of CFS.ResultsThe exposure cohort had a significantly higher overall risk of subsequent CFS than that of the control group [adjusted hazard ratio (Christophi in Inflamm Bowel Dis 18(12):2342-2356, 2012)?=?2.25, 95%, confidence interval (Aaron and Buchwald in Ann Intern Med 134(9 Pt 2):868-881, 2001; Farraye et al. in Am J Gastroenterol 112:241, 2017) 1.70-2.99]. Further analysis indicated a significantly higher risk of CFS in patients who were male (HR?=?3.23, 95% CI 2.12-4.91), were older than 35 years, and had IBD but without comorbidity status, e.g. Cancers, diabetes, obesity, depression, anxiety, sleep disorder, renal disease (HR?=?2.50, 95% CI 1.63-3.84) after adjustment.ConclusionThe findings from this population-based retrospective cohort study suggest that IBD, especially Crohn's disease, is associated with an increased risk of subsequent CFS.

Dataset Information

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Background

Methods

Results

Discussion

Publications

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Similar Datasets

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