Dataset Information

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

ABSTRACT:

Background

The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.

Methods

We conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of PID), and comorbidity. Cox proportional hazard regression was used to evaluate the risk of subsequent PD.

Results

At the final follow-up, a total of 176 (3.26%) and 275 (2.55%) individuals developed PD in the case and control groups, respectively. Patients with PID have a higher risk of developing PD (adjusted hazard ratio = 1.431, 95% CI [1.141-1.794], p = 0.002).

Discussion

Our results show that PID is associated with an increased risk of developing PD. Whilst these findings suggest that reducing PID may modify the risk of developing PD, further study will be needed.

SUBMITTER: Chen CK

PROVIDER: S-EPMC5554596 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Chen Chang-Kai CK Wu Yung-Tsan YT Chang Yu-Chao YC

PeerJ 20170810

<h4>Background</h4>The cause-effect relation between periodontal inflammatory disease (PID) and Parkinson's disease (PD) remains uncertain. The purpose of our study was to investigate the association between PID and PD.<h4>Methods</h4>We conducted a retrospective matched-cohort study by using Taiwan's National Health Insurance Research Database. We identified 5,396 patients with newly diagnosed PID during 1997-2004 and 10,792 cases without PID by matching sex, age, index of year (occurrence of P ...[more]

PMID: 28828251

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Project description:BackgroundAlthough emerging evidence suggests that periodontitis might increase the risk of cancer, comorbidity and lifestyle behaviors, such as smoking and body mass index (BMI), may have confounded this reported association. This study aimed to investigate whether chronic periodontitis is associated with cancer risk using a large, nationwide database.MethodsWe conducted a population-based, retrospective cohort study using data from the Korean National Health Insurance Cohort Database obtained between January 2003 and December 2015. We included 713,201 individuals without a history of cancer who were followed up to 10 years. Confounding factors included demographic factors (age, sex, income, and residential area), lifestyle behaviors (smoking history and BMI), and comorbidities, such as hypertension, diabetes, heart failure, and pulmonary disease, using the Charlson Comorbidity Index. Multivariable Cox regression analysis was applied to estimate the adjusted hazard ratio (aHR) for cancer risk.ResultsOf the 713,201 participants, 53,075 had periodontitis and were placed in the periodontitis group; the remaining 660,126 individuals were included as the control group. Overall, the cumulative incidence of cancer in the periodontitis group was 2.2 times higher than that in the control group. The periodontitis group had an increased risk of total cancer compared to the control group after adjusting for age, sex, comorbidities, BMI, and smoking history (aHR, 1.129; 95% confidence interval [CI], 1.089-1.171; P<0.0001). When examining specific cancer types, significant associations were also observed between periodontitis and stomach cancer (aHR, 1.136; 95% CI, 1.042-1.239; P=0.0037), colon cancer (aHR, 1.129; 95% CI, 1.029-1.239; P=0.0105), lung cancer (aHR, 1.127; 95% CI, 1.008-1.260; P=0.0353), bladder cancer (aHR, 1.307; 95% CI, 1.071-1.595; P=0.0085), thyroid cancer (aHR, 1.191; 95% CI, 1.085-1.308; P=0.0002), and leukemia (aHR, 1.394; 95% CI, 1.039-1.872; P=0.0270). There was no significant association between the development of secondary malignancy and periodontitis in cancer survivors who were alive 5 years after they were diagnosed with the primary malignancy.ConclusionsPeriodontal disease, including periodontitis, was associated with increased risk of cancer, which persisted after controlling for confounding factors. Further prospective research is warranted to establish a causal relationship.

Dataset Information

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Background

Methods

Results

Discussion

Publications

Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study.

Similar Datasets

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