Dataset Information

Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan.

ABSTRACT: BACKGROUND:The progressive neurodegenerative disorder Parkinson disease (PD) is well-established as the second most common neurodegenerative disease. Associations between the sequential risk of PD and gout have been addressed in other studies, but findings have been inconclusive. Accordingly, we executed the present study with the purpose of assessing PD risk in patients with gout. METHODS:From Taiwan's National Health Insurance Research Database, we identified the data of patients newly diagnosed as having gout between January 1, 2000 and December 1, 2000. A cohort of patients without gout, matched for sex and age, was constructed for comparison. Hazard ratios (HRs) and the incidence rate of subsequent PD were calculated for both cohorts and separately for male and female groups. The gout and comparison cohorts consisted of 7900 patients each. RESULTS:The HR for PD was not significantly higher in the gout cohort compared with the control cohort (HR 1.01, 95% confidence interval [CI], 0.93-1.31, P?=?.268), even after adjustment for age, urbanization, monthly income, sex, and comorbidities. We did not observe gender differences in the gout-PD association (male: HR 1.01, 95% CI, 0.88-1.36, P?=?.400; female: HR 1.11, 95% CI, 0.84-1.46, P?=?.466). CONCLUSIONS:Our study identified that there was no protective effect of gout for the risk of PD in the Taiwanese population.

SUBMITTER: Hu LY

PROVIDER: S-EPMC7487828 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan.

Hu Li-Yu LY Yang Albert C AC Lee Shyh-Chyang SC You Zi-Hong ZH Tsai Shih-Jen SJ Hu Chang-Kuo CK Shen Cheng-Che CC

BMC neurology 20200908 1

<h4>Background</h4>The progressive neurodegenerative disorder Parkinson disease (PD) is well-established as the second most common neurodegenerative disease. Associations between the sequential risk of PD and gout have been addressed in other studies, but findings have been inconclusive. Accordingly, we executed the present study with the purpose of assessing PD risk in patients with gout.<h4>Methods</h4>From Taiwan's National Health Insurance Research Database, we identified the data of patient ...[more]

PMID: 32900384

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Project description:ObjectiveWhile gout is associated with cardiovascular (CV)-metabolic comorbidities and their sequelae, the antioxidant effects of uric acid may have neuroprotective benefits. We evaluated the potential impact of incident gout on the risk of developing Alzheimer's disease (AD) in a general population context.MethodsWe conducted an age-matched, sex-matched, entry-time-matched and body mass index (BMI)-matched cohort study using data from The Health Improvement Network, an electronic medical record database representative of the UK general population, from 1 January 1995 to 31 December 2013. Up to five non-gout individuals were matched to each case of incident gout by age, sex, year of enrolment and BMI. We compared incidence rates of AD between the gout and comparison cohorts, excluding individuals with prevalent gout or dementia at baseline. Multivariate hazard ratios (HRs) were calculated, while adjusting for smoking, alcohol use, physician visits, social deprivation index, comorbidities and medication use. We repeated the same analysis among patients with incident osteoarthritis (OA) as a negative control exposure.ResultsWe identified 309 new cases of AD among 59 224 patients with gout (29% female, mean age 65 years) and 1942 cases among 238 805 in the comparison cohort over a 5-year median follow up (1.0 vs 1.5 per 1000 person-years, respectively). Univariate (age-matched, sex-matched, entry-time-matched and BMI-matched) and multivariate HRs for AD among patients with gout were 0.71 (95% CI 0.62 to 0.80) and 0.76 (95% CI 0.66 to 0.87), respectively. The inverse association persisted among subgroups stratified by sex, age group (<75 and ≥75 years), social deprivation index and history of CV disease. The association between incident OA and the risk of incident AD was null.ConclusionsThese findings provide the first general population-based evidence that gout is inversely associated with the risk of developing AD, supporting the purported potential neuroprotective role of uric acid.

Dataset Information

Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan.

Publications

Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan.

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