Alternative Splicing May Not Be the Key to Proteome Complexity.
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ABSTRACT:
SUBMITTER: Tress ML
PROVIDER: S-EPMC6526280 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Alternative Splicing May Not Be the Key to Proteome Complexity.
Tress Michael L ML Abascal Federico F Valencia Alfonso A
Trends in biochemical sciences 20161003 2
Alternative splicing is commonly believed to be a major source of cellular protein diversity. However, although many thousands of alternatively spliced transcripts are routinely detected in RNA-seq studies, reliable large-scale mass spectrometry-based proteomics analyses identify only a small fraction of annotated alternative isoforms. The clearest finding from proteomics experiments is that most human genes have a single main protein isoform, while those alternative isoforms that are identified ...[more]
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