The idiosyncratic drug-induced gene expression changes in HepG2 cells.
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ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC5554930 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
The idiosyncratic drug-induced gene expression changes in HepG2 cells.
Jiang J J Mathijs K K Timmermans L L Claessen S M SM Hecka A A Weusten J J Peters R R van Delft J H JH Kleinjans J C S JCS Jennen D G J DGJ de Kok T M TM
Data in brief 20170729
The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We exposed HepG2 cells with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, in the presence (I+ and N+) or absence (I- and N-) of a cytokine mix for 6, 12 and 24 h. To investigate the genome-wide expression patter ...[more]
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