Ontology highlight
ABSTRACT:
SUBMITTER: Krishnan AR
PROVIDER: S-EPMC5555648 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Krishnan Aswini R AR Zheng Hao H Kwok James G JG Qu Yuanhao Y Zou Angela E AE Korrapati Avinaash A Li Pin Xue PX Califano Joseph A JA Hovell Melbourne F MF Wang-Rodriguez Jessica J Ongkeko Weg M WM
Oral oncology 20170713
<h4>Objective</h4>While tobacco smoking is a well-known risk factor for head and neck squamous cell carcinoma (HNSCC), the molecular mechanisms underlying tobacco-induced HNSCC remain unclear. This study sought to comprehensively identify microRNA (miRNA) alterations and evaluate their clinical relevance in smoking-induced HNSCC pathogenesis and progression.<h4>Materials and methods</h4>Using small RNA-sequencing data and clinical data from 145 HNSCC patients, we performed a series of differenti ...[more]