Ontology highlight
ABSTRACT:
SUBMITTER: Ghasemi F
PROVIDER: S-EPMC6485669 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Ghasemi Farhad F Prokopec Stephenie D SD MacNeil Danielle D Mundi Neil N Gameiro Steven F SF Howlett Christopher C Stecho William W Plantinga Paul P Pinto Nicole N Ruicci Kara M KM Khan Mohammed Imran MI Yoo John J Fung Kevin K Sahovaler Axel A Palma David A DA Winquist Eric E Mymryk Joe S JS Barrett John W JW Boutros Paul C PC Nichols Anthony C AC
JCI insight 20190110 1
Smoking has historically been recognized as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences between heavy smokers (>20 pack years) and never smokers among the HNSCC patients within The Cancer Genome Atlas (TCGA). Single nucleotide variation and copy number aberration differences between heavy smokers and never smokers were compared within human papillomavirus-positive (HPV-positive) (n = 67) and HPV-negative (n ...[more]