Ontology highlight
ABSTRACT:
SUBMITTER: Imperatore F
PROVIDER: S-EPMC5556267 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Imperatore Francesco F Maurizio Julien J Vargas Aguilar Stephanie S Busch Clara J CJ Favret Jérémy J Kowenz-Leutz Elisabeth E Cathou Wilfried W Gentek Rebecca R Perrin Pierre P Leutz Achim A Berruyer Carole C Sieweke Michael H MH
The EMBO journal 20170712 16
Mature differentiated macrophages can self-maintain by local proliferation in tissues and can be extensively expanded in culture under specific conditions, but the mechanisms of this phenomenon remain only partially defined. Here, we show that SIRT1, an evolutionary conserved regulator of life span, positively affects macrophage self-renewal ability <i>in vitro</i> and <i>in vivo</i> Overexpression of SIRT1 during bone marrow-derived macrophage differentiation increased their proliferative capac ...[more]