Ontology highlight
ABSTRACT:
SUBMITTER: Parameswaran S
PROVIDER: S-EPMC4302892 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Parameswaran Sowmya S Xia Xiaohuan X Hegde Ganapati G Ahmad Iqbal I
Development (Cambridge, England) 20141101 21
In vertebrate retina, histogenesis occurs over an extended period. To sustain the temporal generation of diverse cell types, retinal progenitor cells (RPCs) must self-renew. However, self-renewal and regulation of RPCs remain poorly understood. Here, we demonstrate that cell-extrinsic factors coordinate with the epigenetic regulator high-mobility group AT-hook 2 (Hmga2) to regulate self-renewal of late retinal progenitor cells (RPCs). We observed that a small subset of RPCs was capable of clonal ...[more]