Ontology highlight
ABSTRACT:
SUBMITTER: Zaitseva E
PROVIDER: S-EPMC5558241 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zaitseva Elena E Zaitsev Eugene E Melikov Kamran K Arakelyan Anush A Marin Mariana M Villasmil Rafael R Margolis Leonid B LB Melikyan Gregory B GB Chernomordik Leonid V LV
Cell host & microbe 20170701 1
HIV-1 entry into host cells starts with interactions between the viral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors. Previous work has suggested that efficient HIV entry also depends on intracellular signaling, but this remains controversial. Here we report that formation of the pre-fusion Env-CD4-coreceptor complexes triggers non-apoptotic cell surface exposure of the membrane lipid phosphatidylserine (PS). HIV-1-induced PS redistribution depends on Ca<sup>2+</sup> sig ...[more]