A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.
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ABSTRACT:
SUBMITTER: Katt WP
PROVIDER: S-EPMC5558546 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.
Katt William P WP Lukey Michael J MJ Cerione Richard A RA
Future medicinal chemistry 20170123 2
Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenergetic processes. Two isozymes of glutaminase exist, a kidney-type (GLS) and a liver-type enzyme (GLS2 or LGA). While a majority of studies have focused on GLS, here we summarize key findings on both glu ...[more]
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