Dataset Information

Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer.

ABSTRACT:

Background

Recent meta-analyses suggest that pre-diagnostic statin use is associated with reduced breast cancer-specific mortality. Studies have shown that high breast tumour expression of the statin target (3-hydroxy-3-methylglutaryl coenzyme-A reductase) is associated with lymph-node negative cancer. Therefore, we examined the association between pre-diagnostic statin use and; lymph node status, breast cancer-specific and all-cause mortality.

Methods

Women with stages I-III breast cancer were identified from the National Cancer Registry of Ireland (N=6314). Pre-diagnostic statin users were identified from linked prescription claims data (N=2082). Relative risks were estimated for associations between pre-diagnostic statin use and lymph node status. Hazard ratios (HR) were estimated for associations between pre-diagnostic statin use and breast cancer-specific and all-cause mortality.

Results

Pre-diagnostic statin use was not associated with lymph node negative status at diagnosis. In multivariate analyses, pre-diagnostic statin use was associated with reduced all-cause (HR 0.78 95% confidence interval (CI) 0.69, 0.89) and breast cancer-specific mortality (HR 0.81 95% CI 0.68, 0.96). This reduction in cancer-specific mortality was greatest in statin-users with oestrogen (ER) receptor-positive tumours (HR 0.69 95% CI 0.55, 0.85).

Conclusion

Patients with pre-diagnostic statin exposure had a significant reduction in breast cancer-specific mortality, which was even more pronounced in women with ER+ tumours.

SUBMITTER: Smith A

PROVIDER: S-EPMC5558692 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer.

Smith Amelia A Murphy Laura L Zgaga Lina L Barron Thomas I TI Bennett Kathleen K

British journal of cancer 20170718 4

<h4>Background</h4>Recent meta-analyses suggest that pre-diagnostic statin use is associated with reduced breast cancer-specific mortality. Studies have shown that high breast tumour expression of the statin target (3-hydroxy-3-methylglutaryl coenzyme-A reductase) is associated with lymph-node negative cancer. Therefore, we examined the association between pre-diagnostic statin use and; lymph node status, breast cancer-specific and all-cause mortality.<h4>Methods</h4>Women with stages I-III brea ...[more]

PMID: 28720842

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Dataset Information

Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer.

Background

Methods

Results

Conclusion

Publications

Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer.

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