Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection.

ABSTRACT: BACKGROUND:Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs). METHODS:Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4+ T-cell counts. RESULTS:Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT-qPCR (<2 log RNA copies/mL). They maintained healthy CD4+ T-cell counts of >500 cells/?L blood, while CD4 counts in the vast majority of other macaques were below this level. CONCLUSIONS:The M3M4 MHC genotype may confer enhanced control of SIV replication in MCMs.

SUBMITTER: Li H 

PROVIDER: S-EPMC5560087 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature