Ontology highlight
ABSTRACT:
SUBMITTER: Randolph ME
PROVIDER: S-EPMC5560593 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Randolph Matthew E ME Cleary Megan M MM Bajwa Zia Z Svalina Matthew N MN Young Michael C MC Mansoor Atiya A Kaur Pali P Bult Carol J CJ Goros Martin W MW Michalek Joel E JE Xiang Sunny S Keck James J Krasnoperov Valery V Gill Parkash P Keller Charles C
PloS one 20170817 8
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma affecting children and is often diagnosed with concurrent metastases. Unfortunately, few effective therapies have been discovered that improve the long-term survival rate for children with metastatic disease. Here we determined effectiveness of targeting the receptor tyrosine kinase, EphB4, in both alveolar and embryonal RMS either directly through the inhibitory antibody, VasG3, or indirectly by blocking both forward and reverse sign ...[more]