Ontology highlight
ABSTRACT:
SUBMITTER: Cutler SJ
PROVIDER: S-EPMC5561029 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cutler Samuel J SJ Doecke James D JD Ghazawi Ibtisam I Yang Jinbo J Griffiths Lyn R LR Spring Kevin J KJ Ralph Stephen J SJ Mellick Albert S AS
Scientific reports 20170817 1
Dynamic remodelling of the extracellular matrix (ECM) is a key feature of cancer progression. Enzymes that modify the ECM, such as matrix metalloproteinases (MMPs), have long been recognised as important targets of anticancer therapy. Inflammatory cytokines are known to play a key role in regulating protease expression in cancer. Here we describe the identification of gamma-activated site (GAS)-like, signal transducer and activator of transcription (STAT) binding elements (SBEs) within the prox ...[more]