Ontology highlight
ABSTRACT:
SUBMITTER: Gupta MK
PROVIDER: S-EPMC5561171 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Gupta Manish K MK Kaminski Rafal R Mullen Brian B Gordon Jennifer J Burdo Tricia H TH Cheung Joseph Y JY Feldman Arthur M AM Madesh Muniswamy M Khalili Kamel K
Scientific reports 20170817 1
Cardiovascular disease is a leading cause of co-morbidity in HIV-1 positive patients, even those in whom plasma virus levels are well-controlled. The pathogenic mechanism of HIV-1-associated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the absence of productive HIV-1 replication in cardiomyocytes. We sought to investigate the effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infected CD4+ T cells on protein quality ...[more]