Ontology highlight
ABSTRACT:
SUBMITTER: Pavlos R
PROVIDER: S-EPMC5561238 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Pavlos Rebecca R McKinnon Elizabeth J EJ Ostrov David A DA Peters Bjoern B Buus Soren S Koelle David D Chopra Abha A Schutte Ryan R Rive Craig C Redwood Alec A Restrepo Susana S Bracey Austin A Kaever Thomas T Myers Paisley P Speers Ellen E Malaker Stacy A SA Shabanowitz Jeffrey J Jing Yuan Y Gaudieri Silvana S Hunt Donald F DF Carrington Mary M Haas David W DW Mallal Simon S Phillips Elizabeth J EJ
Scientific reports 20170817 1
Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediated drug hypersensitivity syndromes. Nevirapine (NVP), is an HIV-1 antiretroviral with treatment-limiting hypersensitivity reactions (HSRs) associated with multiple class I and II HLA alleles. Here we utilize a novel analytical approach to explore these multi- ...[more]