Proteomics

Dataset Information

0

Public T cell epitopes shared among SARS-CoV-2 Public T cell epitopes shared among SARS-CoV-2 variants are presented on prevalent HLA class I alleles variants are presented on prevalent HLA class I alleles

ABSTRACT: In this project, we used MS-based immunopeptidomics and T-cell screening assays to identify SARS-CoV-2 epitopes. The MS identified epitopes were further valdiated for CD8 T cell immunogenecity. PBMC from a large number of patients infected with SARS-CoV-2 were used for valdiation of MS identifed and predected CD 8 T cell epotipes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell

SUBMITTER: Ravi Chand Bollineni  

LAB HEAD: Johanna Olweus

PROVIDER: PXD028862 | Pride | 2023-03-11

REPOSITORIES: pride

Json Xml

Dataset's files

Source:
Action DRS
Peaks.zip Other
RB_200709_A01_EnvMembrane.raw Raw
RB_200709_A01_Nucleocapsid.raw Raw
RB_200709_A01_Spike.raw Raw
RB_200709_A01_Spike2_turncated.raw Raw
Items per page:
1 - 5 of 65
altmetric image

Publications

The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that mediate escape from neutralizing antibodies. There is also evidence that mutations can cause loss of T cell epitopes. However, studies on viral escape from T cell immunity have been hampered by uncertain estimates of epitope prevalence. Here, we map and quantify CD8 T cell responses to SARS-CoV-2-specific minimal epitopes in blood drawn from April to June 2020 from 83 COVID-19 convalescents. Among 37 HLA ligands el  ...[more]

Similar Datasets

Proteomics Identification of naturally-presented influenza A virus CD8+ T cell epitopes
2024-05-22 | PXD035241 | Pride
Proteomics Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells
2021-07-09 | PXD021672 | Pride
Proteomics Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
2023-04-07 | PXD034773 | Pride
Proteomics Presentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
2024-05-24 | PXD042316 | Pride
Unknown The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles.
| S-EPMC9934604 | biostudies-literature
Proteomics Thunder-DDA-PASEF boosted by MS2rescore enables high-coverage immunopeptidomics and identifies HLA class-I presented SarsCoV-2 spike protein epitopes
2024-03-19 | PXD046535 | Pride
Unknown Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics.
| S-EPMC8185308 | biostudies-literature
Unknown Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.
| S-EPMC5561238 | biostudies-literature
Unknown In silico characterization of immunogenic epitopes presented by HLA-Cw*0401.
| S-EPMC2040137 | biostudies-literature
Unknown Lack of HLA predominance and HLA shared epitopes in biliary Atresia.
| S-EPMC3595468 | biostudies-literature