?-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.
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ABSTRACT:
SUBMITTER: Kang CW
PROVIDER: S-EPMC5561724 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.
Kang Chang Won CW Sarnowski Matthew P MP Ranatunga Sujeewa S Wojtas Lukasz L Metcalf Rainer S RS Guida Wayne C WC Del Valle Juan R JR
Chemical communications (Cambridge, England) 20151101 90
Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits. ...[more]
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