Ontology highlight
ABSTRACT:
SUBMITTER: Mathur D
PROVIDER: S-EPMC5562025 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mathur Deepti D Stratikopoulos Elias E Ozturk Sait S Steinbach Nicole N Pegno Sarah S Schoenfeld Sarah S Yong Raymund R Murty Vundavalli V VV Asara John M JM Cantley Lewis C LC Parsons Ramon R
Cancer discovery 20170302 4
Metabolic changes induced by oncogenic drivers of cancer contribute to tumor growth and are attractive targets for cancer treatment. Here, we found that increased growth of <i>PTEN</i>-mutant cells was dependent on glutamine flux through the <i>de novo</i> pyrimidine synthesis pathway, which created sensitivity to the inhibition of dihydroorotate dehydrogenase, a rate-limiting enzyme for pyrimidine ring synthesis. S-phase <i>PTEN</i>-mutant cells showed increased numbers of replication forks, an ...[more]