Ontology highlight
ABSTRACT:
SUBMITTER: Drummond DA
PROVIDER: S-EPMC556249 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Drummond D Allan DA Silberg Jonathan J JJ Meyer Michelle M MM Wilke Claus O CO Arnold Frances H FH
Proceedings of the National Academy of Sciences of the United States of America 20050404 15
Intragenic recombination rapidly creates protein sequence diversity compared with random mutation, but little is known about the relative effects of recombination and mutation on protein function. Here, we compare recombination of the distantly related beta-lactamases PSE-4 and TEM-1 to mutation of PSE-4. We show that, among beta-lactamase variants containing the same number of amino acid substitutions, variants created by recombination retain function with a significantly higher probability tha ...[more]