Capsid-Dependent Host Factors in HIV-1 Infection.
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ABSTRACT:
SUBMITTER: Yamashita M
PROVIDER: S-EPMC5562514 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Capsid-Dependent Host Factors in HIV-1 Infection.
Yamashita Masahiro M Engelman Alan N AN
Trends in microbiology 20170518 9
After invasion of a susceptible target cell, HIV-1 completes the early phase of its life cycle upon integration of reverse-transcribed viral DNA into host chromatin. The viral capsid, a conical shell encasing the viral ribonucleoprotein complex, along with its constitutive capsid protein, plays essential roles at virtually every step in the early phase of the viral life cycle. Recent work has begun to reveal how the viral capsid interacts with specific cellular proteins to promote these processe ...[more]
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