Ontology highlight
ABSTRACT:
SUBMITTER: Foo JC
PROVIDER: S-EPMC5563804 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Foo Jerome Clifford JC Noori Hamid Reza HR Yamaguchi Ikuhiro I Vengeliene Valentina V Cosa-Linan Alejandro A Nakamura Toru T Morita Kenji K Spanagel Rainer R Yamamoto Yoshiharu Y
Proceedings. Biological sciences 20170801 1860
The theory of critical transitions in complex systems (ecosystems, climate, etc.), and especially its ability to predict abrupt changes by early-warning signals based on analysis of fluctuations close to tipping points, is seen as a promising avenue to study disease dynamics. However, the biomedical field still lacks a clear demonstration of this concept. Here, we used a well-established animal model in which initial alcohol exposure followed by deprivation and subsequent reintroduction of alcoh ...[more]