Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3314989 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Chen Luonan L Liu Rui R Liu Zhi-Ping ZP Li Meiyi M Aihara Kazuyuki K
Scientific reports 20120329
Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition from one state to another at a tipping point. Here, we develop a model-free method to detect early-warning signals of such critical transitions, even with only a small number of samples. Specifically, we theoretically derive an index based on a dynamical network biomarker (DNB) that serves as a general early-warning sign ...[more]