Incoherent Inputs Enhance the Robustness of Biological Oscillators.

ABSTRACT: Robust biological oscillators retain the critical ability to function in the presence of environmental perturbations. Although central architectures that support robust oscillations have been extensively studied, networks containing the same core vary drastically in their potential to oscillate, and it remains elusive what peripheral modifications to the core contribute to this functional variation. Here, we have generated a complete atlas of two- and three-node oscillators computationally, then systematically analyzed the association between network structure and robustness. We found that, while certain core topologies are essential for producing a robust oscillator, local structures can substantially modulate the robustness of oscillations. Notably, local nodes receiving incoherent or co

SUBMITTER: Li Z 

PROVIDER: S-EPMC5564455 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature