Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC5564459 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Liu Jiancheng J Wu Xiwei X Zhang Heying H Pfeifer Gerd P GP Lu Qiang Q
Cell reports 20170801 6
During cellular differentiation, genes important for differentiation are expected to be silent in stem/progenitor cells yet can be readily activated. RNA polymerase II (Pol II) pausing and bivalent chromatin marks are two paradigms suited for establishing such a poised state of gene expression; however, their specific contributions in development are not well understood. Here we characterized Pol II pausing and H3K4me3/H3K27me3 marks in neural progenitor cells (NPCs) and their daughter neurons p ...[more]