Ontology highlight
ABSTRACT:
SUBMITTER: Shen L
PROVIDER: S-EPMC5564777 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Shen Le L Zhang Lu-Lu LL Li Hui H Liu Xiao X Yu Xiao-Xuan XX Hu Po P Hui Hui H Guo Qing-Long QL Zhang Shuai S
Oncotarget 20170701 30
Oroxylin A (OA), a naturally occurring monoflavonoid isolated from Scutellariae radix, has previously been reported to inhibit the proliferation of several cancer cell lines. CD4+CD25+Foxp3+ regulatory T cells (Tregs) play an important role in maintenance of immunologic self-tolerance. Tregs also increase in cancer and take part in suppressing antitumor immune responses. Here, we explored how OA affected the Tregs in lung cancer environment and the involved underlying mechanism. It is found that ...[more]