HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells.
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ABSTRACT:
SUBMITTER: Korner C
PROVIDER: S-EPMC5565794 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells.
Körner Christian C Simoneau Camille R CR Schommers Philipp P Granoff Mitchell M Ziegler Maja M Hölzemer Angelique A Lunemann Sebastian S Chukwukelu Janet J Corleis Björn B Naranbhai Vivek V Kwon Douglas S DS Scully Eileen P EP Jost Stephanie S Kirchhoff Frank F Carrington Mary M Altfeld Marcus M
Cell host & microbe 20170701 1
It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity ...[more]
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