Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring ?-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease.

ABSTRACT: Development of sensitive detectors of A? aggregates and effective inhibitors of A? aggregation are of diagnostic importance and therapeutic implications for Alzheimer's disease (AD) treatment. Herein, a novel strategy has been presented by self-assembly of peptide conjugated Au nanorods (AuP) as multifunctional A? fibrillization detectors and inhibitors. Our design combines the unique high NIR absorption property of AuNRs with two known A? inhibitors, A?15-20 and polyoxometalates (POMs). The synthesized AuP can effectively inhibit A? aggregation and dissociate amyloid deposits with NIR irradiation both in buffer and in mice cerebrospinal fluid (CSF), and protect cells from A?-related toxicity upon NIR irradiation. In addition, with the shape and size-dependent optical properties, the nanorods can also act as effective diagnostic probes to sensitively detect the A? aggregates. This is the first report to integrate 3 segments, an A?-targeting element, a reporter and inhibitors, in one drug delivery system for AD treatment.

SUBMITTER: Li M 

PROVIDER: S-EPMC5566101 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature