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Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform.

ABSTRACT: A sensitive turn-on luminescent sensor for H₂O₂ based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H₂O₂, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, H₂O₂ can oxidize AgNPs to soluble Ag⁺ cations, which restores the luminescence of Ir-1. The sensing platform displayed a sensitive response to H₂O₂ in the range of 0-17??M, with a detection limit of 0.3??M. Importantly, the probe was successfully applied to monitor intracellular H₂O₂ in living cells, and it also showed high selectivity for H₂O₂ over other interfering substances.

SUBMITTER: Liu J

PROVIDER: S-EPMC5566206 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform.

Liu Jinshui J Dong Zhen-Zhen ZZ Yang Chao C Li Guodong G Wu Chun C Lee Fu-Wa FW Leung Chung-Hang CH Ma Dik-Lung DL

Scientific reports 20170821 1

A sensitive turn-on luminescent sensor for H2O2 based on the silver nanoparticle (AgNP)-mediated quenching of an luminescent Ir(III) complex (Ir-1) has been designed. In the absence of H2O2, the luminescence intensity of Ir-1 can be quenched by AgNPs via non-radiative energy transfer. However, H2O2 can oxidize AgNPs to soluble Ag+ cations, which restores the luminescence of Ir-1. The sensing platform displayed a sensiti ...[more]

PMID: 28827747

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