A prospective analysis of mucosal microbiome-metabonome interactions in colorectal cancer using a combined MAS 1HNMR and metataxonomic strategy.
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ABSTRACT:
SUBMITTER: Kinross J
PROVIDER: S-EPMC5566496 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
A prospective analysis of mucosal microbiome-metabonome interactions in colorectal cancer using a combined MAS 1HNMR and metataxonomic strategy.
Kinross James J Mirnezami Reza R Alexander James J Brown Richard R Scott Alasdair A Galea Dieter D Veselkov Kirill K Goldin Rob R Darzi Ara A Nicholson Jeremy J Marchesi Julian R JR
Scientific reports 20170821 1
Colon cancer induces a state of mucosal dysbiosis with associated niche specific changes in the gut microbiota. However, the key metabolic functions of these bacteria remain unclear. We performed a prospective observational study in patients undergoing elective surgery for colon cancer without mechanical bowel preparation (n = 18). Using 16 S rRNA gene sequencing we demonstrated that microbiota ecology appears to be cancer stage-specific and strongly associated with histological features of poor ...[more]
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