Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan A
PROVIDER: S-EPMC5567863 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Nagarajan Arvindhan A Dogra Shaillay Kumar SK Sun Lisha L Gandotra Neeru N Ho Thuy T Cai Guoping G Cline Gary G Kumar Priti P Cowles Robert A RA Wajapeyee Narendra N
Molecular cell 20170810 4
Metabolic deregulation is a hallmark of human cancers, and the glycolytic and glutamine metabolism pathways were shown to be deregulated in pancreatic ductal adenocarcinoma (PDAC). To identify new metabolic regulators of PDAC tumor growth and metastasis, we systematically knocked down metabolic genes that were overexpressed in human PDAC tumor samples using short hairpin RNAs. We found that p53 transcriptionally represses paraoxonase 2 (PON2), which regulates GLUT1-mediated glucose transport via ...[more]