Ontology highlight
ABSTRACT:
SUBMITTER: Bechard ME
PROVIDER: S-EPMC7426874 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bechard Matthew E ME Smalling Rana R Hayashi Akimasa A Zhong Yi Y Word Anna E AE Campbell Sydney L SL Tran Amanda V AV Weiss Vivian L VL Iacobuzio-Donahue Christine C Wellen Kathryn E KE McDonald Oliver G OG
Nature communications 20200813 1
Although metastasis is the most common cause of cancer deaths, metastasis-intrinsic dependencies remain largely uncharacterized. We previously reported that metastatic pancreatic cancers were dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Surprisingly, PGD catalysis was constitutively elevated without activating mutations, suggesting a non-genetic basis for enhanced activity. Here we report a metabolic adaptation that stably activates PGD to reprogram metastat ...[more]