Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC5568332 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Song Jiho J Kang Hae Ju HJ Lee Jung Wuk JW Wenas Michelle A MA Jeong Seung Hwarn SH Lee Taeho T Oh Kyungsoo K Min Kyung Hoon KH
PloS one 20170823 8
In view of the few reports concerning aromatic nucleophilic substitution reactions featuring an alkoxy group as a leaving group, the aromatic nucleophilic substitution of 2,4-dimethoxynitrobenzene was investigated with a bulky t-butoxide nucleophile under microwave irradiation. The transetherification of 2,4-dimethoxynitrobenezene with sodium t-butoxide under specific conditions, namely for 20 min at 110°C in 10% dimethoxyethane in toluene, afforded the desired product in 87% yield with exclusiv ...[more]