Ontology highlight
ABSTRACT:
SUBMITTER: McNulty SM
PROVIDER: S-EPMC5568664 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20170801 3
Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organization of distinct alpha satellite arrays. Active and inactive arrays on the same chromosome produce discrete sets of transcripts in cis. Non-coding RNAs produced from active arrays are ...[more]