Ontology highlight
ABSTRACT:
SUBMITTER: Milling TJ
PROVIDER: S-EPMC5568758 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Milling Truman J TJ Kaatz Scott S
The American journal of emergency medicine 20160928 11S
Oral Factor Xa (FXa) inhibitors, a growing class of direct-acting anticoagulants, are frequently used to prevent stroke and systemic embolism in patients with atrial fibrillation and to prevent and treat venous thromboembolism. These drugs reduce the risk of clotting at the expense of increasing the risk of bleeding, and currently they have no specific reversal agent. However, andexanet alfa, a recombinant modified FXa decoy molecule, is in a late-phase clinical trial in bleeding patients, and c ...[more]