Ontology highlight
ABSTRACT:
SUBMITTER: Kelly RJ
PROVIDER: S-EPMC3297681 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Kelly Ronan J RJ Sharon Elad E Pastan Ira I Hassan Raffit R
Molecular cancer therapeutics 20120217 3
Mesothelin is a tumor differentiation antigen that is highly expressed in several malignant diseases in humans, including malignant mesothelioma and pancreatic, ovarian, and lung adenocarcinomas. The limited expression of mesothelin on normal human tissues and its high expression in many common cancers make it an attractive candidate for cancer therapy. Several agents, including an immunotoxin, monoclonal antibody, antibody drug conjugate, and tumor vaccine, are in various stages of development ...[more]