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Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells.

ABSTRACT: We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration changes in living cells, and detecting intracellular Zn(II) ions released from intracellular metalloproteins.

SUBMITTER: Zhang S

PROVIDER: S-EPMC5569883 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells.

Zhang Shuwei S Adhikari Rashmi R Fang Mingxi M Dorh Nethaniah N Li Cong C Jaishi Meghnath M Zhang Jingtuo J Tiwari Ashutosh A Pati Ranjit R Luo Fen-Tair FT Liu Haiying H

ACS sensors 20161117 12

We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration ...[more]

PMID: 28845457

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