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Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells.


ABSTRACT: We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration changes in living cells, and detecting intracellular Zn(II) ions released from intracellular metalloproteins.

SUBMITTER: Zhang S 

PROVIDER: S-EPMC5569883 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells.

Zhang Shuwei S   Adhikari Rashmi R   Fang Mingxi M   Dorh Nethaniah N   Li Cong C   Jaishi Meghnath M   Zhang Jingtuo J   Tiwari Ashutosh A   Pati Ranjit R   Luo Fen-Tair FT   Liu Haiying H  

ACS sensors 20161117 12


We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration  ...[more]

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