Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.
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ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC5570498 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.
Ge Xinwei X Kakinen Aleksandr A Gurzov Esteban N EN Yang Wen W Pang Lokman L Pilkington Emily H EH Govindan-Nedumpully Praveen P Chen Pengyu P Separovic Frances F Davis Thomas P TP Ke Pu Chun PC Ding Feng F
Chemical communications (Cambridge, England) 20170801 68
Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation. ...[more]
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