Ontology highlight
ABSTRACT:
SUBMITTER: Nedumpully-Govindan P
PROVIDER: S-EPMC4725907 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nedumpully-Govindan Praveen P Kakinen Aleksandr A Pilkington Emily H EH Davis Thomas P TP Chun Ke Pu P Ding Feng F
Scientific reports 20160114
Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect on the aggregation of several proteins. Here, we use discrete molecular dynamics (DMD) simulations and high-throughput dynamic light scattering (DLS) experiments to study the anti-aggregation effects of two polyphenols, curcumin and resveratrol, on the aggregation of islet amyloid polypeptide (IAPP or amylin). Our DMD simulations suggest that the aggregation inhibition is caused by stabilization of s ...[more]