Ontology highlight
ABSTRACT:
SUBMITTER: Einarsdottir E
PROVIDER: S-EPMC5570950 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Einarsdottir Elisabet E Peyrard-Janvid Myriam M Darki Fahimeh F Tuulari Jetro J JJ Merisaari Harri H Karlsson Linnea L Scheinin Noora M NM Saunavaara Jani J Parkkola Riitta R Kantojärvi Katri K Ämmälä Antti-Jussi AJ Yiu-Lin Yu Nancy N Matsson Hans H Nopola-Hemmi Jaana J Karlsson Hasse H Paunio Tiina T Klingberg Torkel T Leinonen Eira E Kere Juha J
Scientific reports 20170824 1
A whole-genome linkage analysis in a Finnish pedigree of eight cases with developmental dyslexia (DD) revealed several regions shared by the affected individuals. Analysis of coding variants from two affected individuals identified rs146011974G > A (Ala1039Thr), a rare variant within the NCAN gene co-segregating with DD in the pedigree. This variant prompted us to consider this gene as a putative candidate for DD. The RNA expression pattern of the NCAN gene in human tissues was highly correlated ...[more]