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Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.

ABSTRACT: Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.

SUBMITTER: Jahangiri A

PROVIDER: S-EPMC5571827 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.

Jahangiri Arman A Chin Aaron T AT Flanigan Patrick M PM Chen Rebecca R Bankiewicz Krystof K Aghi Manish K MK

Journal of neurosurgery 20160401 1

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeu ...[more]

PMID: 27035164

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Convection-enhanced drug delivery for glioblastoma: a review.

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