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Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics.

ABSTRACT: Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood-brain barrier by facilitating concentrated local therapeutic drug delivery with limited systemic effects. Here, we present a concise review of properties essential for safe and efficient convection-enhanced drug delivery, as well as a focused review of clinical studies evaluating CED in the treatment of glioblastoma.

SUBMITTER: Ung TH

PROVIDER: S-EPMC6088338 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics.

Ung Timothy H TH Malone Hani H Canoll Peter P Bruce Jeffrey N JN

CNS oncology 20150624 4

Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood-brain barrier by facilitating concentrated local therapeu ...[more]

PMID: 26103989

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| S-EPMC9332136 | biostudies-literature

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