Dataset Information

Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.

ABSTRACT:

Background

We aimed to quantitatively assess the potential relationship between kidney stones and coronary heart disease or stroke.

Methods

A meta-analysis was conducted on eligibly studies published before 31 May 2016 in PubMed or Embase. The data were pooled, and the relationship was assessed by the random-effect model with inverse variance-weighted procedure. The results were expressed as relative risk (RR) with 95% confidence intervals (95%CI).

Results

Eight studies of 11 cohorts (n?=?11) were included in our analysis with 3,658,360 participants and 157,037 cases. We found that a history of kidney stones was associated with increased risk of coronary heart disease (CHD) (RR?=?1.24; 95%CI: 1.14-1.36; I?=?79.0%, n?=?11); similar effect on myocardial infarction, a serious condition of CHD, was observed (RR?=?1.24; 95%CI: 1.10-1.40; I?=?80.4%, n?=?8). We also found that a history of kidney stones may increase the risk of stroke (RR?=?1.21, 95%CI: 1.06-1.38; I?=?54.7%, n?=?4). In subgroup analysis, the risk of coronary heart disease was higher in men (RR?=?1.23, 95%CI: 1.02-1.49) while the risk for stroke was higher in women (RR?=?1.12; 95%CI: 1.03-1.21). No obvious publications bias was detected (Egger test: P?=?.47).

Conclusion

Kidney stones are associated with increased risk of coronary heart disease and stroke, and the effect may differ by sex.

SUBMITTER: Peng JP

PROVIDER: S-EPMC5572031 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.

Peng Jian-Ping JP Zheng Hang H

Medicine 20170801 34

<h4>Background</h4>We aimed to quantitatively assess the potential relationship between kidney stones and coronary heart disease or stroke.<h4>Methods</h4>A meta-analysis was conducted on eligibly studies published before 31 May 2016 in PubMed or Embase. The data were pooled, and the relationship was assessed by the random-effect model with inverse variance-weighted procedure. The results were expressed as relative risk (RR) with 95% confidence intervals (95%CI).<h4>Results</h4>Eight studies of ...[more]

PMID: 28834909

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Dataset Information

Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.

Background

Methods

Results

Conclusion

Publications

Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.

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