Ontology highlight
ABSTRACT:
SUBMITTER: Gupta A
PROVIDER: S-EPMC5572747 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20170621 9
Intracellular compartmentalization and trafficking of molecules plays a critical role in complex and essential cellular processes. In lung cancer and other malignancies, aberrant nucleocytoplasmic transport of tumor suppressor proteins and cell cycle regulators results in tumorigenesis and inactivation of apoptosis. Pharmacologic agents targeting this process, termed selective inhibitors of nuclear export (SINE), have demonstrated antitumor efficacy in preclinical models and human clinical trial ...[more]